CovidSeniorV1, Main, Exploration, bibRecord, 000526

Hydroxychloroquine and azithromycin tolerance in haemodialysis patients during COVID-19 infection.

Identifieur interne : 000526 ( Main/Exploration ); précédent : 000525; suivant : 000527

Hydroxychloroquine and azithromycin tolerance in haemodialysis patients during COVID-19 infection.

Auteurs : Philippe Giaime [France] ; Maxime Guenoun [France] ; Nathalie Pedinielli [France] ; Hervé Narbonne [France] ; Jean-Philippe Bergounioux [France] ; Caroline Solas [France] ; Romain Guilhaumou [France] ; Jérôme Sampol [France] ; Jacques Ollier [France] ; Hélène Sichez [France] ; Marianne Serveaux [France] ; Flora Brunner [France] ; Stanislas Bataille [France]

Source :

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association [ 1460-2385 ] ; 2020.

RBID : pubmed:32844224

Descripteurs français

KwdFr :
- Antibactériens (usage thérapeutique), Antipaludiques (usage thérapeutique), Azithromycine (usage thérapeutique), Betacoronavirus (MeSH), Comorbidité (MeSH), Dialyse rénale (méthodes), Défaillance rénale chronique (thérapie), Défaillance rénale chronique (épidémiologie), Femelle (MeSH), France (épidémiologie), Humains (MeSH), Hydroxychloroquine (usage thérapeutique), Infections à coronavirus (traitement médicamenteux), Infections à coronavirus (épidémiologie), Mâle (MeSH), Pandémies (MeSH), Pneumopathie virale (traitement médicamenteux), Pneumopathie virale (épidémiologie), Sujet âgé (MeSH), Tolérance aux médicaments (MeSH).
MESH :
- méthodes : Dialyse rénale.
- thérapie : Défaillance rénale chronique.
- traitement médicamenteux : Infections à coronavirus, Pneumopathie virale.
- usage thérapeutique : Antibactériens, Antipaludiques, Azithromycine, Hydroxychloroquine.
- épidémiologie : Défaillance rénale chronique, France, Infections à coronavirus, Pneumopathie virale.
- Betacoronavirus, Comorbidité, Femelle, Humains, Mâle, Pandémies, Sujet âgé, Tolérance aux médicaments.
Wicri :
- geographic : France.

English descriptors

KwdEn :
- Aged (MeSH), Anti-Bacterial Agents (therapeutic use), Antimalarials (therapeutic use), Azithromycin (therapeutic use), Betacoronavirus (MeSH), Comorbidity (MeSH), Coronavirus Infections (drug therapy), Coronavirus Infections (epidemiology), Drug Tolerance (MeSH), Female (MeSH), France (epidemiology), Humans (MeSH), Hydroxychloroquine (therapeutic use), Kidney Failure, Chronic (epidemiology), Kidney Failure, Chronic (therapy), Male (MeSH), Pandemics (MeSH), Pneumonia, Viral (drug therapy), Pneumonia, Viral (epidemiology), Renal Dialysis (methods).
MESH :
- chemical , therapeutic use : Anti-Bacterial Agents, Antimalarials, Azithromycin, Hydroxychloroquine.
- geographic , epidemiology : France.
- drug therapy : Coronavirus Infections, Pneumonia, Viral.
- epidemiology : Coronavirus Infections, Kidney Failure, Chronic, Pneumonia, Viral.
- methods : Renal Dialysis.
- therapy : Kidney Failure, Chronic.
- Aged, Betacoronavirus, Comorbidity, Drug Tolerance, Female, Humans, Male, Pandemics.

Abstract

BACKGROUND

Haemodialysis patients are at risk of developing severe forms of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection: coronavirus disease 2019 (COVID-19). In March 2020, hydroxychloroquine (HCQ) and azithromycin (AZI) were proposed as potential treatments of COVID-19, but with warnings concerning their possible toxicity. No data are available regarding the toxicity of this treatment in haemodialysis patients.

METHODS

We report the use of HCQ and AZI in a cohort of COVID-19 haemodialysis patients with focus on safety concerns.

RESULTS

Twenty-one patients received 200 mg HCQ thrice daily during 10 days, and AZI 500 mg on Day 1, and 250 mg on the four following days. HCQ plasma concentrations were within the recommended range (0.1-1.0 µg/mL) in all patients except one, in which maximum concentration was 1.1 µg/mL. HCQ concentration raised until the third day and remained stable thereafter. No cardiac event occurred in spite of progressive lengthening of corrected QT interval (QTc) during the treatment. One patient experienced a long QTc syndrome (QTc >500 ms) without any arrhythmia episode, although HCQ concentration was in the target range. Five (23.8%) patients experienced hypoglycaemia, a well-known HCQ side-effect. SARS-CoV-2 RNA remained detectable in nasopharyngeal swabs for a long time in haemodialysis patients (mean time 21 days).

CONCLUSIONS

HCQ and AZI are safe in haemodialysis patients at these doses but can lead to long QTc syndrome and hypoglycaemia. HCQ concentrations were not correlated with side effects. We recommend monitoring of the QTc length throughout treatment, as well as glycaemia. SARS-CoV-2 could persist for longer in haemodialysis patients than in the general population.

DOI: 10.1093/ndt/gfaa191
PubMed: 32844224
PubMed Central: PMC7499716

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000489
to stream Main, to step Curation: 000489

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Hydroxychloroquine and azithromycin tolerance in haemodialysis patients during COVID-19 infection.</title>
<author><name sortKey="Giaime, Philippe" sort="Giaime, Philippe" uniqKey="Giaime P" first="Philippe" last="Giaime">Philippe Giaime</name>
<affiliation wicri:level="3"><nlm:affiliation>Phocean Nephrology Institute, Clinique Bouchard, Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Phocean Nephrology Institute, Clinique Bouchard, Marseille</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Association pour le Traitement des Urémiques en Provence, Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Association pour le Traitement des Urémiques en Provence, Marseille</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Guenoun, Maxime" sort="Guenoun, Maxime" uniqKey="Guenoun M" first="Maxime" last="Guenoun">Maxime Guenoun</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Cardiology, Clinique Bouchard, Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Cardiology, Clinique Bouchard, Marseille</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pedinielli, Nathalie" sort="Pedinielli, Nathalie" uniqKey="Pedinielli N" first="Nathalie" last="Pedinielli">Nathalie Pedinielli</name>
<affiliation wicri:level="3"><nlm:affiliation>Phocean Nephrology Institute, Clinique Bouchard, Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Phocean Nephrology Institute, Clinique Bouchard, Marseille</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Association pour le Traitement des Urémiques en Provence, Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Association pour le Traitement des Urémiques en Provence, Marseille</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Narbonne, Herve" sort="Narbonne, Herve" uniqKey="Narbonne H" first="Hervé" last="Narbonne">Hervé Narbonne</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Endocrinology, Clinique Bouchard, Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Endocrinology, Clinique Bouchard, Marseille</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bergounioux, Jean Philippe" sort="Bergounioux, Jean Philippe" uniqKey="Bergounioux J" first="Jean-Philippe" last="Bergounioux">Jean-Philippe Bergounioux</name>
<affiliation wicri:level="3"><nlm:affiliation>Laboratoire Cerballiance Provence, Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire Cerballiance Provence, Marseille</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Solas, Caroline" sort="Solas, Caroline" uniqKey="Solas C" first="Caroline" last="Solas">Caroline Solas</name>
<affiliation wicri:level="4"><nlm:affiliation>Aix-Marseille Université, APHM, Unité des Virus Emergents (UVE) IRD 190, INSERM 1207, Laboratoire de Pharmacocinétique et Toxicologie, Hôpital La Timone, Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Aix-Marseille Université, APHM, Unité des Virus Emergents (UVE) IRD 190, INSERM 1207, Laboratoire de Pharmacocinétique et Toxicologie, Hôpital La Timone, Marseille</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
<orgName type="university">Université d'Aix-Marseille</orgName>
</affiliation>
</author>
<author><name sortKey="Guilhaumou, Romain" sort="Guilhaumou, Romain" uniqKey="Guilhaumou R" first="Romain" last="Guilhaumou">Romain Guilhaumou</name>
<affiliation wicri:level="4"><nlm:affiliation>Service de Pharmacologie Clinique et Pharmacovigilance, APHM, Institut de Neurosciences des Systèmes, Inserm UMR 1106, Université d'Aix-Marseille, Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service de Pharmacologie Clinique et Pharmacovigilance, APHM, Institut de Neurosciences des Systèmes, Inserm UMR 1106, Université d'Aix-Marseille, Marseille</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
<orgName type="university">Université d'Aix-Marseille</orgName>
</affiliation>
</author>
<author><name sortKey="Sampol, Jerome" sort="Sampol, Jerome" uniqKey="Sampol J" first="Jérôme" last="Sampol">Jérôme Sampol</name>
<affiliation wicri:level="3"><nlm:affiliation>Phocean Nephrology Institute, Clinique Bouchard, Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Phocean Nephrology Institute, Clinique Bouchard, Marseille</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Association pour le Traitement des Urémiques en Provence, Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Association pour le Traitement des Urémiques en Provence, Marseille</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ollier, Jacques" sort="Ollier, Jacques" uniqKey="Ollier J" first="Jacques" last="Ollier">Jacques Ollier</name>
<affiliation wicri:level="3"><nlm:affiliation>Phocean Nephrology Institute, Clinique Bouchard, Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Phocean Nephrology Institute, Clinique Bouchard, Marseille</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Association pour le Traitement des Urémiques en Provence, Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Association pour le Traitement des Urémiques en Provence, Marseille</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sichez, Helene" sort="Sichez, Helene" uniqKey="Sichez H" first="Hélène" last="Sichez">Hélène Sichez</name>
<affiliation wicri:level="3"><nlm:affiliation>Phocean Nephrology Institute, Clinique Bouchard, Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Phocean Nephrology Institute, Clinique Bouchard, Marseille</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Association pour le Traitement des Urémiques en Provence, Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Association pour le Traitement des Urémiques en Provence, Marseille</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Serveaux, Marianne" sort="Serveaux, Marianne" uniqKey="Serveaux M" first="Marianne" last="Serveaux">Marianne Serveaux</name>
<affiliation wicri:level="3"><nlm:affiliation>Phocean Nephrology Institute, Clinique Bouchard, Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Phocean Nephrology Institute, Clinique Bouchard, Marseille</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Association pour le Traitement des Urémiques en Provence, Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Association pour le Traitement des Urémiques en Provence, Marseille</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Brunner, Flora" sort="Brunner, Flora" uniqKey="Brunner F" first="Flora" last="Brunner">Flora Brunner</name>
<affiliation wicri:level="3"><nlm:affiliation>Phocean Nephrology Institute, Clinique Bouchard, Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Phocean Nephrology Institute, Clinique Bouchard, Marseille</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Association pour le Traitement des Urémiques en Provence, Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Association pour le Traitement des Urémiques en Provence, Marseille</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bataille, Stanislas" sort="Bataille, Stanislas" uniqKey="Bataille S" first="Stanislas" last="Bataille">Stanislas Bataille</name>
<affiliation wicri:level="3"><nlm:affiliation>Phocean Nephrology Institute, Clinique Bouchard, Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Phocean Nephrology Institute, Clinique Bouchard, Marseille</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:affiliation>Aix Marseille Université, INSERM, INRAE, C2VN, Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Aix Marseille Université, INSERM, INRAE, C2VN, Marseille</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
<orgName type="university">Université d'Aix-Marseille</orgName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2020">2020</date>
<idno type="RBID">pubmed:32844224</idno>
<idno type="pmid">32844224</idno>
<idno type="doi">10.1093/ndt/gfaa191</idno>
<idno type="pmc">PMC7499716</idno>
<idno type="wicri:Area/Main/Corpus">000489</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000489</idno>
<idno type="wicri:Area/Main/Curation">000489</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000489</idno>
<idno type="wicri:Area/Main/Exploration">000489</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Hydroxychloroquine and azithromycin tolerance in haemodialysis patients during COVID-19 infection.</title>
<author><name sortKey="Giaime, Philippe" sort="Giaime, Philippe" uniqKey="Giaime P" first="Philippe" last="Giaime">Philippe Giaime</name>
<affiliation wicri:level="3"><nlm:affiliation>Phocean Nephrology Institute, Clinique Bouchard, Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Phocean Nephrology Institute, Clinique Bouchard, Marseille</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Association pour le Traitement des Urémiques en Provence, Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Association pour le Traitement des Urémiques en Provence, Marseille</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Guenoun, Maxime" sort="Guenoun, Maxime" uniqKey="Guenoun M" first="Maxime" last="Guenoun">Maxime Guenoun</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Cardiology, Clinique Bouchard, Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Cardiology, Clinique Bouchard, Marseille</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pedinielli, Nathalie" sort="Pedinielli, Nathalie" uniqKey="Pedinielli N" first="Nathalie" last="Pedinielli">Nathalie Pedinielli</name>
<affiliation wicri:level="3"><nlm:affiliation>Phocean Nephrology Institute, Clinique Bouchard, Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Phocean Nephrology Institute, Clinique Bouchard, Marseille</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Association pour le Traitement des Urémiques en Provence, Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Association pour le Traitement des Urémiques en Provence, Marseille</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Narbonne, Herve" sort="Narbonne, Herve" uniqKey="Narbonne H" first="Hervé" last="Narbonne">Hervé Narbonne</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Endocrinology, Clinique Bouchard, Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Endocrinology, Clinique Bouchard, Marseille</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bergounioux, Jean Philippe" sort="Bergounioux, Jean Philippe" uniqKey="Bergounioux J" first="Jean-Philippe" last="Bergounioux">Jean-Philippe Bergounioux</name>
<affiliation wicri:level="3"><nlm:affiliation>Laboratoire Cerballiance Provence, Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire Cerballiance Provence, Marseille</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Solas, Caroline" sort="Solas, Caroline" uniqKey="Solas C" first="Caroline" last="Solas">Caroline Solas</name>
<affiliation wicri:level="4"><nlm:affiliation>Aix-Marseille Université, APHM, Unité des Virus Emergents (UVE) IRD 190, INSERM 1207, Laboratoire de Pharmacocinétique et Toxicologie, Hôpital La Timone, Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Aix-Marseille Université, APHM, Unité des Virus Emergents (UVE) IRD 190, INSERM 1207, Laboratoire de Pharmacocinétique et Toxicologie, Hôpital La Timone, Marseille</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
<orgName type="university">Université d'Aix-Marseille</orgName>
</affiliation>
</author>
<author><name sortKey="Guilhaumou, Romain" sort="Guilhaumou, Romain" uniqKey="Guilhaumou R" first="Romain" last="Guilhaumou">Romain Guilhaumou</name>
<affiliation wicri:level="4"><nlm:affiliation>Service de Pharmacologie Clinique et Pharmacovigilance, APHM, Institut de Neurosciences des Systèmes, Inserm UMR 1106, Université d'Aix-Marseille, Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service de Pharmacologie Clinique et Pharmacovigilance, APHM, Institut de Neurosciences des Systèmes, Inserm UMR 1106, Université d'Aix-Marseille, Marseille</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
<orgName type="university">Université d'Aix-Marseille</orgName>
</affiliation>
</author>
<author><name sortKey="Sampol, Jerome" sort="Sampol, Jerome" uniqKey="Sampol J" first="Jérôme" last="Sampol">Jérôme Sampol</name>
<affiliation wicri:level="3"><nlm:affiliation>Phocean Nephrology Institute, Clinique Bouchard, Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Phocean Nephrology Institute, Clinique Bouchard, Marseille</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Association pour le Traitement des Urémiques en Provence, Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Association pour le Traitement des Urémiques en Provence, Marseille</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ollier, Jacques" sort="Ollier, Jacques" uniqKey="Ollier J" first="Jacques" last="Ollier">Jacques Ollier</name>
<affiliation wicri:level="3"><nlm:affiliation>Phocean Nephrology Institute, Clinique Bouchard, Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Phocean Nephrology Institute, Clinique Bouchard, Marseille</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Association pour le Traitement des Urémiques en Provence, Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Association pour le Traitement des Urémiques en Provence, Marseille</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sichez, Helene" sort="Sichez, Helene" uniqKey="Sichez H" first="Hélène" last="Sichez">Hélène Sichez</name>
<affiliation wicri:level="3"><nlm:affiliation>Phocean Nephrology Institute, Clinique Bouchard, Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Phocean Nephrology Institute, Clinique Bouchard, Marseille</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Association pour le Traitement des Urémiques en Provence, Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Association pour le Traitement des Urémiques en Provence, Marseille</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Serveaux, Marianne" sort="Serveaux, Marianne" uniqKey="Serveaux M" first="Marianne" last="Serveaux">Marianne Serveaux</name>
<affiliation wicri:level="3"><nlm:affiliation>Phocean Nephrology Institute, Clinique Bouchard, Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Phocean Nephrology Institute, Clinique Bouchard, Marseille</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Association pour le Traitement des Urémiques en Provence, Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Association pour le Traitement des Urémiques en Provence, Marseille</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Brunner, Flora" sort="Brunner, Flora" uniqKey="Brunner F" first="Flora" last="Brunner">Flora Brunner</name>
<affiliation wicri:level="3"><nlm:affiliation>Phocean Nephrology Institute, Clinique Bouchard, Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Phocean Nephrology Institute, Clinique Bouchard, Marseille</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Association pour le Traitement des Urémiques en Provence, Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Association pour le Traitement des Urémiques en Provence, Marseille</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bataille, Stanislas" sort="Bataille, Stanislas" uniqKey="Bataille S" first="Stanislas" last="Bataille">Stanislas Bataille</name>
<affiliation wicri:level="3"><nlm:affiliation>Phocean Nephrology Institute, Clinique Bouchard, Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Phocean Nephrology Institute, Clinique Bouchard, Marseille</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:affiliation>Aix Marseille Université, INSERM, INRAE, C2VN, Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Aix Marseille Université, INSERM, INRAE, C2VN, Marseille</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
<orgName type="university">Université d'Aix-Marseille</orgName>
</affiliation>
</author>
</analytic>
<series><title level="j">Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association</title>
<idno type="eISSN">1460-2385</idno>
<imprint><date when="2020" type="published">2020</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged (MeSH)</term>
<term>Anti-Bacterial Agents (therapeutic use)</term>
<term>Antimalarials (therapeutic use)</term>
<term>Azithromycin (therapeutic use)</term>
<term>Betacoronavirus (MeSH)</term>
<term>Comorbidity (MeSH)</term>
<term>Coronavirus Infections (drug therapy)</term>
<term>Coronavirus Infections (epidemiology)</term>
<term>Drug Tolerance (MeSH)</term>
<term>Female (MeSH)</term>
<term>France (epidemiology)</term>
<term>Humans (MeSH)</term>
<term>Hydroxychloroquine (therapeutic use)</term>
<term>Kidney Failure, Chronic (epidemiology)</term>
<term>Kidney Failure, Chronic (therapy)</term>
<term>Male (MeSH)</term>
<term>Pandemics (MeSH)</term>
<term>Pneumonia, Viral (drug therapy)</term>
<term>Pneumonia, Viral (epidemiology)</term>
<term>Renal Dialysis (methods)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Antibactériens (usage thérapeutique)</term>
<term>Antipaludiques (usage thérapeutique)</term>
<term>Azithromycine (usage thérapeutique)</term>
<term>Betacoronavirus (MeSH)</term>
<term>Comorbidité (MeSH)</term>
<term>Dialyse rénale (méthodes)</term>
<term>Défaillance rénale chronique (thérapie)</term>
<term>Défaillance rénale chronique (épidémiologie)</term>
<term>Femelle (MeSH)</term>
<term>France (épidémiologie)</term>
<term>Humains (MeSH)</term>
<term>Hydroxychloroquine (usage thérapeutique)</term>
<term>Infections à coronavirus (traitement médicamenteux)</term>
<term>Infections à coronavirus (épidémiologie)</term>
<term>Mâle (MeSH)</term>
<term>Pandémies (MeSH)</term>
<term>Pneumopathie virale (traitement médicamenteux)</term>
<term>Pneumopathie virale (épidémiologie)</term>
<term>Sujet âgé (MeSH)</term>
<term>Tolérance aux médicaments (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anti-Bacterial Agents</term>
<term>Antimalarials</term>
<term>Azithromycin</term>
<term>Hydroxychloroquine</term>
</keywords>
<keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>France</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Coronavirus Infections</term>
<term>Kidney Failure, Chronic</term>
<term>Pneumonia, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Renal Dialysis</term>
</keywords>
<keywords scheme="MESH" qualifier="méthodes" xml:lang="fr"><term>Dialyse rénale</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Kidney Failure, Chronic</term>
</keywords>
<keywords scheme="MESH" qualifier="thérapie" xml:lang="fr"><term>Défaillance rénale chronique</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à coronavirus</term>
<term>Pneumopathie virale</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antibactériens</term>
<term>Antipaludiques</term>
<term>Azithromycine</term>
<term>Hydroxychloroquine</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Défaillance rénale chronique</term>
<term>France</term>
<term>Infections à coronavirus</term>
<term>Pneumopathie virale</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Betacoronavirus</term>
<term>Comorbidity</term>
<term>Drug Tolerance</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Pandemics</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Betacoronavirus</term>
<term>Comorbidité</term>
<term>Femelle</term>
<term>Humains</term>
<term>Mâle</term>
<term>Pandémies</term>
<term>Sujet âgé</term>
<term>Tolérance aux médicaments</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>France</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b>
</p>
<p>Haemodialysis patients are at risk of developing severe forms of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection: coronavirus disease 2019 (COVID-19). In March 2020, hydroxychloroquine (HCQ) and azithromycin (AZI) were proposed as potential treatments of COVID-19, but with warnings concerning their possible toxicity. No data are available regarding the toxicity of this treatment in haemodialysis patients.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>METHODS</b>
</p>
<p>We report the use of HCQ and AZI in a cohort of COVID-19 haemodialysis patients with focus on safety concerns.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>Twenty-one patients received 200 mg HCQ thrice daily during 10 days, and AZI 500 mg on Day 1, and 250 mg on the four following days. HCQ plasma concentrations were within the recommended range (0.1-1.0 µg/mL) in all patients except one, in which maximum concentration was 1.1 µg/mL. HCQ concentration raised until the third day and remained stable thereafter. No cardiac event occurred in spite of progressive lengthening of corrected QT interval (QTc) during the treatment. One patient experienced a long QTc syndrome (QTc >500 ms) without any arrhythmia episode, although HCQ concentration was in the target range. Five (23.8%) patients experienced hypoglycaemia, a well-known HCQ side-effect. SARS-CoV-2 RNA remained detectable in nasopharyngeal swabs for a long time in haemodialysis patients (mean time 21 days).</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b>
</p>
<p>HCQ and AZI are safe in haemodialysis patients at these doses but can lead to long QTc syndrome and hypoglycaemia. HCQ concentrations were not correlated with side effects. We recommend monitoring of the QTc length throughout treatment, as well as glycaemia. SARS-CoV-2 could persist for longer in haemodialysis patients than in the general population.</p>
</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" IndexingMethod="Curated" Owner="NLM"><PMID Version="1">32844224</PMID>
<DateCompleted><Year>2020</Year>
<Month>09</Month>
<Day>15</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>09</Month>
<Day>22</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1460-2385</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>35</Volume>
<Issue>8</Issue>
<PubDate><Year>2020</Year>
<Month>08</Month>
<Day>01</Day>
</PubDate>
</JournalIssue>
<Title>Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association</Title>
<ISOAbbreviation>Nephrol Dial Transplant</ISOAbbreviation>
</Journal>
<ArticleTitle>Hydroxychloroquine and azithromycin tolerance in haemodialysis patients during COVID-19 infection.</ArticleTitle>
<Pagination><MedlinePgn>1346-1353</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1093/ndt/gfaa191</ELocationID>
<Abstract><AbstractText Label="BACKGROUND">Haemodialysis patients are at risk of developing severe forms of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection: coronavirus disease 2019 (COVID-19). In March 2020, hydroxychloroquine (HCQ) and azithromycin (AZI) were proposed as potential treatments of COVID-19, but with warnings concerning their possible toxicity. No data are available regarding the toxicity of this treatment in haemodialysis patients.</AbstractText>
<AbstractText Label="METHODS">We report the use of HCQ and AZI in a cohort of COVID-19 haemodialysis patients with focus on safety concerns.</AbstractText>
<AbstractText Label="RESULTS">Twenty-one patients received 200 mg HCQ thrice daily during 10 days, and AZI 500 mg on Day 1, and 250 mg on the four following days. HCQ plasma concentrations were within the recommended range (0.1-1.0 µg/mL) in all patients except one, in which maximum concentration was 1.1 µg/mL. HCQ concentration raised until the third day and remained stable thereafter. No cardiac event occurred in spite of progressive lengthening of corrected QT interval (QTc) during the treatment. One patient experienced a long QTc syndrome (QTc >500 ms) without any arrhythmia episode, although HCQ concentration was in the target range. Five (23.8%) patients experienced hypoglycaemia, a well-known HCQ side-effect. SARS-CoV-2 RNA remained detectable in nasopharyngeal swabs for a long time in haemodialysis patients (mean time 21 days).</AbstractText>
<AbstractText Label="CONCLUSIONS">HCQ and AZI are safe in haemodialysis patients at these doses but can lead to long QTc syndrome and hypoglycaemia. HCQ concentrations were not correlated with side effects. We recommend monitoring of the QTc length throughout treatment, as well as glycaemia. SARS-CoV-2 could persist for longer in haemodialysis patients than in the general population.</AbstractText>
<CopyrightInformation>© The Author(s) 2020. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Giaime</LastName>
<ForeName>Philippe</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Phocean Nephrology Institute, Clinique Bouchard, Marseille, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Association pour le Traitement des Urémiques en Provence, Marseille, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Guenoun</LastName>
<ForeName>Maxime</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Cardiology, Clinique Bouchard, Marseille, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pedinielli</LastName>
<ForeName>Nathalie</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>Phocean Nephrology Institute, Clinique Bouchard, Marseille, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Association pour le Traitement des Urémiques en Provence, Marseille, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Narbonne</LastName>
<ForeName>Hervé</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Department of Endocrinology, Clinique Bouchard, Marseille, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bergounioux</LastName>
<ForeName>Jean-Philippe</ForeName>
<Initials>JP</Initials>
<AffiliationInfo><Affiliation>Laboratoire Cerballiance Provence, Marseille, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Solas</LastName>
<ForeName>Caroline</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Aix-Marseille Université, APHM, Unité des Virus Emergents (UVE) IRD 190, INSERM 1207, Laboratoire de Pharmacocinétique et Toxicologie, Hôpital La Timone, Marseille, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Guilhaumou</LastName>
<ForeName>Romain</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Service de Pharmacologie Clinique et Pharmacovigilance, APHM, Institut de Neurosciences des Systèmes, Inserm UMR 1106, Université d'Aix-Marseille, Marseille, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sampol</LastName>
<ForeName>Jérôme</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Phocean Nephrology Institute, Clinique Bouchard, Marseille, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Association pour le Traitement des Urémiques en Provence, Marseille, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ollier</LastName>
<ForeName>Jacques</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Phocean Nephrology Institute, Clinique Bouchard, Marseille, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Association pour le Traitement des Urémiques en Provence, Marseille, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sichez</LastName>
<ForeName>Hélène</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Phocean Nephrology Institute, Clinique Bouchard, Marseille, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Association pour le Traitement des Urémiques en Provence, Marseille, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Serveaux</LastName>
<ForeName>Marianne</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Phocean Nephrology Institute, Clinique Bouchard, Marseille, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Association pour le Traitement des Urémiques en Provence, Marseille, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Brunner</LastName>
<ForeName>Flora</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Phocean Nephrology Institute, Clinique Bouchard, Marseille, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Association pour le Traitement des Urémiques en Provence, Marseille, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bataille</LastName>
<ForeName>Stanislas</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Phocean Nephrology Institute, Clinique Bouchard, Marseille, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Aix Marseille Université, INSERM, INRAE, C2VN, Marseille, France.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D064888">Observational Study</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Nephrol Dial Transplant</MedlineTA>
<NlmUniqueID>8706402</NlmUniqueID>
<ISSNLinking>0931-0509</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000900">Anti-Bacterial Agents</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000962">Antimalarials</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>4QWG6N8QKH</RegistryNumber>
<NameOfSubstance UI="D006886">Hydroxychloroquine</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>83905-01-5</RegistryNumber>
<NameOfSubstance UI="D017963">Azithromycin</NameOfSubstance>
</Chemical>
</ChemicalList>
<SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName>
<SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName>
</SupplMeshList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000900" MajorTopicYN="N">Anti-Bacterial Agents</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000962" MajorTopicYN="N">Antimalarials</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017963" MajorTopicYN="N">Azithromycin</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="Y">Betacoronavirus</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015897" MajorTopicYN="N">Comorbidity</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName>
<QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004361" MajorTopicYN="Y">Drug Tolerance</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005602" MajorTopicYN="N" Type="Geographic">France</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006886" MajorTopicYN="N">Hydroxychloroquine</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007676" MajorTopicYN="N">Kidney Failure, Chronic</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
<QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName>
<QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006435" MajorTopicYN="N">Renal Dialysis</DescriptorName>
<QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">COVID-19</Keyword>
<Keyword MajorTopicYN="Y">SARS-CoV-2</Keyword>
<Keyword MajorTopicYN="Y">azithromycin</Keyword>
<Keyword MajorTopicYN="Y">haemodialysis</Keyword>
<Keyword MajorTopicYN="Y">hydroxychloroquine</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year>
<Month>05</Month>
<Day>08</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2020</Year>
<Month>06</Month>
<Day>23</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2020</Year>
<Month>8</Month>
<Day>28</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2020</Year>
<Month>9</Month>
<Day>17</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2020</Year>
<Month>8</Month>
<Day>27</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">32844224</ArticleId>
<ArticleId IdType="pii">5897181</ArticleId>
<ArticleId IdType="doi">10.1093/ndt/gfaa191</ArticleId>
<ArticleId IdType="pmc">PMC7499716</ArticleId>
</ArticleIdList>
<ReferenceList><Reference><Citation>BMJ. 2020 May 14;369:m1849</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32409561</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>JAMA. 2020 Feb 25;323(8):709-710</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31999307</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell Res. 2020 Mar;30(3):269-271</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32020029</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>G Ital Nefrol. 2020 Apr 9;37(2):</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32281756</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biosci Trends. 2020 Mar 16;14(1):72-73</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32074550</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Travel Med Infect Dis. 2020 Mar - Apr;34:101663</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32289548</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Jan 1;1072:320-327</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29207305</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Arthritis Rheumatol. 2015 May;67(8):2176-84</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25989906</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Rheumatol. 1999 Jan;26(1):195-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9918262</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>JAMA. 2020 May 12;323(18):1824-1836</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32282022</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Kidney Int. 2020 Jul;98(1):235-236</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32471636</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Med. 2020 Jun;26(6):808-809</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32488217</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Int J Antimicrob Agents. 2020 Jul;56(1):105949</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32205204</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>JAMA. 2020 Apr 7;323(13):1239-1242</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32091533</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Crit Care. 2020 Mar 18;24(1):108</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32188484</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Infect Control Hosp Epidemiol. 2020 Oct;41(10):1240-1242</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32321619</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>JAMA. 2020 Apr 28;323(16):1574-1581</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32250385</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Zhejiang Da Xue Xue Bao Yi Xue Ban. 2020 May 25;49(2):215-219</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32391667</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Infect Dis. 2020 Jul 28;71(15):732-739</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32150618</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Heart Rhythm. 2008 Jul;5(7):1015-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18598957</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Electrocardiol. 2007 Jul;40(3):228-34</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17276451</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Kidney Int. 2020 May;97(5):829-838</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32247631</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>BMJ Case Rep. 2018 Apr 18;2018:</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29669768</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Med Mal Infect. 2020 Jun;50(4):384</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32240719</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2020 Jun 18;382(25):2411-2418</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32379955</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Thorax. 2003 Aug;58(8):686-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12885985</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>France</li>
</country>
<region><li>Provence-Alpes-Côte d'Azur</li>
</region>
<settlement><li>Marseille</li>
</settlement>
<orgName><li>Université d'Aix-Marseille</li>
</orgName>
</list>
<tree><country name="France"><region name="Provence-Alpes-Côte d'Azur"><name sortKey="Giaime, Philippe" sort="Giaime, Philippe" uniqKey="Giaime P" first="Philippe" last="Giaime">Philippe Giaime</name>
</region>
<name sortKey="Bataille, Stanislas" sort="Bataille, Stanislas" uniqKey="Bataille S" first="Stanislas" last="Bataille">Stanislas Bataille</name>
<name sortKey="Bataille, Stanislas" sort="Bataille, Stanislas" uniqKey="Bataille S" first="Stanislas" last="Bataille">Stanislas Bataille</name>
<name sortKey="Bergounioux, Jean Philippe" sort="Bergounioux, Jean Philippe" uniqKey="Bergounioux J" first="Jean-Philippe" last="Bergounioux">Jean-Philippe Bergounioux</name>
<name sortKey="Brunner, Flora" sort="Brunner, Flora" uniqKey="Brunner F" first="Flora" last="Brunner">Flora Brunner</name>
<name sortKey="Brunner, Flora" sort="Brunner, Flora" uniqKey="Brunner F" first="Flora" last="Brunner">Flora Brunner</name>
<name sortKey="Giaime, Philippe" sort="Giaime, Philippe" uniqKey="Giaime P" first="Philippe" last="Giaime">Philippe Giaime</name>
<name sortKey="Guenoun, Maxime" sort="Guenoun, Maxime" uniqKey="Guenoun M" first="Maxime" last="Guenoun">Maxime Guenoun</name>
<name sortKey="Guilhaumou, Romain" sort="Guilhaumou, Romain" uniqKey="Guilhaumou R" first="Romain" last="Guilhaumou">Romain Guilhaumou</name>
<name sortKey="Narbonne, Herve" sort="Narbonne, Herve" uniqKey="Narbonne H" first="Hervé" last="Narbonne">Hervé Narbonne</name>
<name sortKey="Ollier, Jacques" sort="Ollier, Jacques" uniqKey="Ollier J" first="Jacques" last="Ollier">Jacques Ollier</name>
<name sortKey="Ollier, Jacques" sort="Ollier, Jacques" uniqKey="Ollier J" first="Jacques" last="Ollier">Jacques Ollier</name>
<name sortKey="Pedinielli, Nathalie" sort="Pedinielli, Nathalie" uniqKey="Pedinielli N" first="Nathalie" last="Pedinielli">Nathalie Pedinielli</name>
<name sortKey="Pedinielli, Nathalie" sort="Pedinielli, Nathalie" uniqKey="Pedinielli N" first="Nathalie" last="Pedinielli">Nathalie Pedinielli</name>
<name sortKey="Sampol, Jerome" sort="Sampol, Jerome" uniqKey="Sampol J" first="Jérôme" last="Sampol">Jérôme Sampol</name>
<name sortKey="Sampol, Jerome" sort="Sampol, Jerome" uniqKey="Sampol J" first="Jérôme" last="Sampol">Jérôme Sampol</name>
<name sortKey="Serveaux, Marianne" sort="Serveaux, Marianne" uniqKey="Serveaux M" first="Marianne" last="Serveaux">Marianne Serveaux</name>
<name sortKey="Serveaux, Marianne" sort="Serveaux, Marianne" uniqKey="Serveaux M" first="Marianne" last="Serveaux">Marianne Serveaux</name>
<name sortKey="Sichez, Helene" sort="Sichez, Helene" uniqKey="Sichez H" first="Hélène" last="Sichez">Hélène Sichez</name>
<name sortKey="Sichez, Helene" sort="Sichez, Helene" uniqKey="Sichez H" first="Hélène" last="Sichez">Hélène Sichez</name>
<name sortKey="Solas, Caroline" sort="Solas, Caroline" uniqKey="Solas C" first="Caroline" last="Solas">Caroline Solas</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/CovidSeniorV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000526 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000526 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    CovidSeniorV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:32844224
   |texte=   Hydroxychloroquine and azithromycin tolerance in haemodialysis patients during COVID-19 infection.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:32844224" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a CovidSeniorV1

This area was generated with Dilib version V0.6.37.
Data generation: Thu Oct 15 09:49:45 2020. Site generation: Wed Jan 27 17:10:23 2021

	Serveur d'exploration sur la COVID chez les séniors
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur la COVID chez les séniors

Hydroxychloroquine and azithromycin tolerance in haemodialysis patients during COVID-19 infection.

Hydroxychloroquine and azithromycin tolerance in haemodialysis patients during COVID-19 infection.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki